Cover for Adenosine Receptors and Parkinson's Disease

Adenosine Receptors and Parkinson's Disease

Book ? 2000

Edited by:

Hiroshi Kase, Peter J. Richardson and Peter Jenner

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About the book

Description

This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.

This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.

Key Features

  • Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease
  • Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease
  • Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function
    Proposes a hypothesis of adenosine A2A receptor function in the striatum
  • Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints
  • Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease
  • Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease
  • Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function
    Proposes a hypothesis of adenosine A2A receptor function in the striatum
  • Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints

Details

ISBN

978-0-12-400405-4

Language

English

Published

2000

Copyright

Copyright ? 2000 Elsevier Inc. All rights reserved

Imprint

Academic Press

No. of pages

275

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Editors

Hiroshi Kase

Kyowa Hakko Kogyo Co. Ltd. Pharmaceutical Research and Development Division Chiyoda-ku, Tokyo

Peter J. Richardson

Department of Pharmacology University of Cambridge Cambridge, England

Peter Jenner

Neurodegenerative Diseases Research Centre Division of Pharmacology & Therapeutics Guy's King's & St. Thomas' School of Biomedical Sciences King's College London London, UK